Knowledge graph characteristics of sepsis research based on scientometric study / 中华危重病急救医学

Objective:To illustrate a relatively complete knowledge system (e.g., research outputs, current hotspots, and future trends) in the sepsis field and to help scholars grasp the scientific research direction or clinical focus of treatment.Methods:The relevant literatures of sepsis during the time from 1985 to 2019 in Web of Science database were collected. Sepsis-related research contents were generated using softwares (CiteSpace 5.6.R2 and VOSviewer 1.6.13), which using data mining, information processing and knowledge map methods, to analyze the historical evolution and predict the development trend.Results:A total of 8 189 papers on sepsis were published. The volume of publications were increasing yearly from 1985 to 2019, and reached the top list of 1 276 in 2019. For research contents of sepsis, it has formed the basic characteristics of sepsis which focusing on epidemiological studies and animal experiments. Through cluster analysis, the researches mainly focused on six aspects: septic rat, necrotizingenterocolitis, sepsis-associated encephalopathy, acute kidney injury (AKI), gut-derived sepsis, and inflammatory mediator. And it presented the literature characteristics that related to the injury or dysfunction of intestines, brain, liver, kidney or other organs, but the heart and lung researches were more marginal. Additionally, based on the top key words with the strongest citation bursts, it reflected that the development trend of the continuous attention hotspots with "endotoxin" or "endotoxin shock", the significant attention hotspots with "inflammation", "immunity" and "multiple organ dysfunction syndrome" (MODS), and the novel burst attention hotspots with sepsis management including "diagnosis" and "chemotherapy".Conclusions:Through the hotspots and trends visualization of sepsis, the current researches are prefer to animal experiments, epidemiology, or other basic scientific aspects. Meanwhile, the researches are mostly focusing on inflammatory reaction, immune function or organ dysfunctions. Integrating the knowledge maps of hotspots and trends, based on researches of epidemiology, diagnosis, risk factors, pathogenesis, or treatment, we predict that the future scientific topics will concentrating on childhood sepsis, organ injury mechanism or intervention relating to MODS, and integrated management of sepsis by combining traditional Chinese medicine and Western medicine.

Analysis of medication characteristics of traditional Chinese medicine in treating coronavirus disease-19 based on data mining / 浙江大学学报·医学版

OBJECTIVE@#To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19).@*METHODS@#We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak in Wuhan to February 19, 2020. The frequency analysis, cluster analysis and correlation analysis were performed.@*RESULTS@#The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were , , , and . The commonly used traditional formulations included Decoction, Powder, and Decoction. The Chinese patent drugs included Pill, Injection, and Capsule. The most common paired medications were and , and . Two core combinations and one novel formula were discovered in the study.@*CONCLUSIONS@# Powder and Decoction are the basic formulations for syndrome of COVID-19. In addition, Decoction, Powder, Decoction and Decoction are the basic formulations for syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine.

Analysis of medication characteristics of traditional Chinese medicine in treating COVID-19 based on data mining / 浙江大学学报·医学版

OBJECTIVE@#To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19).@*METHODS@#We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. The frequency analysis, cluster analysis and association analysis were performed.@*RESULTS@#The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were , and . The commonly used traditional formulations included decoction, powder, and decoction. The Chinese patent drugs included pill, injection, and capsule. The most common paired medications were and and Two core combinations and one novel formula were discovered in the study.@*CONCLUSIONS@# powder and decoction are the basic formulations for syndrome of COVID-19. In addition, decoction, powder, decoction and decoction are the basic formulations for syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine.

FAN Wenhu 's Experience in Treating Dampness Prevalent Diseases with Flexible Use of Wetting Method / 浙江中医药大学学报

[Objective]Analysis of the famous doctor FAN Wenhu treatment of dampness prevalent diseases experience with a view to the clinical treatment of it to provide reference.[Methods]By consulting the relevant FAN Wenhu's medical information and screening out the treatment of dampness prevalent diseases of his cases to further analyze and sum up his clinical experience in the treatment of it. [Result] It was found out that he was skilled in using wetting treatments for dampness prevalent diseases, which the wet wilt in the upper body used Qingzhen decoction to clear dampness wetting,the vomid malaria used Huopusini powder to regulate qi and dispel wet, the damp-heat invagination used Huopuwuling powder to activate yang to remove dampness. [Conclusion]FAN Wenhu was flexibled to use varieties of dampness methods in the treatment of dampness prevalent disease in order to eliminate wet evil and isolate hot evil.These cases had accurate effect and distinct treatment characteristics,it is worthy of reference.

Four Notes on Discussing Amnesia by Studying Neijing / 浙江中医药大学学报

Objective]To study the cognization of Huangdi Neijing on the occurrence of amnesia hoping to enlighten the clinical treatment on amnesia. [Method]Analyze and elaborate four articles which are related to amnesia in Huangdi Neijing by studying it, and then summarize the reason of the occurrence of amnesia. [Result]The occurrence of amnesia is closely related to the variation of emotion, the pathology of viscera and the deficiency and excess of qi and blood. Qi deficiency of heart and lung, impairment of liver and kidney and disturbance of qi and blood can result in the occurrence of amnesia. [Conclusion] Huangdi Neijing discusses the occurrence of amnesia in detail, and it has very positive meaning on guiding clinical practice.

Experience of Making Formula and Description on Treatment of Gastric Abscess in Zhang Yuqing’ Medical Records / 浙江中医药大学学报

Objective]The article analyzed and summed up the experience of making formula and description on treatment of gastric abscess in Qing Dynasty Zhang Yuqing’s Medical Records, in order to provide reference in treating contemporary similar diseases.[Methods]Through studying the medical cases of this book,the authors selected out 30 cases of gastric abscess for futher analysis and summing up the Zhang Yuqing’s experience of description.[Result]He usually used the methods to cure gastric abscess, i.e. expelling phlegm by Banxi and Hualou,harmonizing stomach and liver by Zuojin pills, removing obstruction in channels by Xufuhua decoction, tonifying spleen by Liujunzi decoction and Weiling decoction.These cases had accurate effect and distinct treatment characteristics.[Conclusion]Zhang had rich experience in treating gastric abscess, those can broaden insight in treating similar diseases by traditional Chinese medicine,and increase clinical efficacy.

Clinic experience of ZHANG Cheng-lie in differentiating and treating chronic pelvic inflammation / 中华中医药杂志

Professor ZHANG Cheng-lie has been engaged in TCM gynecology for 40 years, who accumulated rich clinical experience in treating chronic pelvic inflammation.In clinic, he combines the syndrome differentiation with differentiantin ofdisease, recognizing yin and yang ofpeople's constitution, researching the mechanism ofpathological changes, then he establishes treatment method according to the syndrome and selects drugs for prescriptions, it gains good effect as a result.The content ofthis article including experiential cases introduces the professor ZHANG's center principle oftreating chronic pelvic inflammation from the aspects ofclearing liver and removing humidity, dispelling cold and removing toxic, invigorating spleen and regulating the Chong channel and dispersing stagnation and dredging the collaterals.